Evidence for paclitaxel from three new endophytic fungi of Himalayan yew of Nepal
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Kanti Shrestha,; Strobel, G, A.; Shrivastava, S, P.; Gewali, M, B. |
| Journal Title | Planta Medica |
| Volume | 67 |
| Pagination | 374-376 |
| ISBN Number | 0032-0943 |
| Key Words | endophytes; medicinal plants; new geographic records; paclitaxel; Taxus; Trichothecium |
| Abstract | Taxus wallichiana , collected from the Himalayan region of Nepal, yielded, among others, three different endophytic fungi including Sporormia minima [ Sporormiella minima ], Trichothecium sp., and an unidentified dimorphic fungus. Each was shown to produce paclitaxel in a culture medium. Each of these fungi represents a new report as a paclitaxel producer. The production of paclitaxel was confirmed by an immunoassay that utilized monoclonal antibodies, TLC chromatography as well as high performance liquid chromatography combined with on-line mass spectrometry. |
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