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Medicinal plants from Nepal; II. Evaluation as inhibitors of lipid peroxidation in biological membranes
| Publication Type | Journal Article |
| Year of Publication | 1999 |
| Authors | Kumar, K, C. S.; Müller, K, |
| Journal Title | Journal of Ethnopharmacology |
| Volume | 64 |
| Pagination | 135-139 |
| ISBN Number | 0378-8741 |
| Key Words | inhibitors; lipid peroxidation; bark; brain; plant extracts; fruits; medicinal plants; screening; liposomes; pharmacology; Aglaia; Clerodendrum; Phyllanthus emblica; Euonymus |
| Abstract | In an ethnopharmacological screening of selected Nepalese medicinal plants, the inhibitory effects on lipid peroxidation of 36 methanolic extracts of 28 different plant species were evaluated using bovine brain phospholipid liposomes as model membranes. Lipid peroxidation was stimulated with the 2,2'-azo- bis-(2-amidinopropane) dihydrochloride. The most potent inhibitor, with an IC50 value of 0.93 micro g/ml, was the extract obtained from the bark of Clerodendrum indicum . The extracts obtained from Aglaia roxburghiana fruits, Euonymus pendulus [ E. lucidus ] bark and Emblica officinalis [ Phyllanthus emblica ] fruits were also active and inhibited lipid peroxidation with IC50 values of 10, 12 and 13 micro g/ml, respectively. The most active extracts were from indigenous plants traditionally used to treat inflammatory diseases. |
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