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Activity of triterpenoid glycosides from the root bark of Mussaenda macrophylla against two oral pathogens
| Publication Type | Journal Article |
| Year of Publication | 1999 |
| Authors | Kim NamCheol,; Desjardins, A, E.; Wu, C, D.; Kinghorn, A, D. |
| Journal Title | Journal of Natural Products |
| Volume | 62 |
| Pagination | 1379-1384 |
| ISBN Number | 0163-3864 |
| Key Words | triterpenoids; glycosides; pathogens; medicinal plants; chemical; structure; plant composition; antibacterial properties; Mussaenda; Porphyromonas gingivalis |
| Abstract | Four new triterpenoid glycosides were isolated from the root bark of M. macrophylla , collected in Nepal. Their structures were determined as 3- O -β-D-glucopyranosyl- 28- O -α-L-rhamnopyranosyl-16α-hydroxy- 23-deoxyprotobassic acid, 28- O -β-D- glucopyranosyl-16α-hydroxy-23-deoxyprotobassic acid, 3- O -β-D-glucopyranosyl-28- O -α- L -rhamnopyranosyl-16α-hydroxyprotobassic acid, and 3- O -{[β-D-glucopyranosyl-(1 right arrow 6)]- O -α-L-rhamnopyranosyl-(1 right arrow 2)- O -β-D-glucopyranosyl-(1 right arrow 2)}- O -β-D-glucopyranosyl-(1 right arrow 3)- O -β-D-glucopyranosyl-cycloarta-22,24-dien- 27-oic acid (mussaendoside W). Four known triterpenoids, 3- O -acetyloleanolic acid, 3- O -acetyldaturadiol, rotundic acid and 16α-hydroxyprotobassic acid were also isolated. The structures of the new compounds were determined by several spectroscopic techniques including 2D NMR methods. Six compounds showed inhibitory activity against a periodontopathic bacterium, Porphyromonas gingivalis , but were inactive against the cariogenic organism, Streptococcus mutans . |
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